IMPURITIES AVAILABLE FOR 'Geldanamycin'

Omsynth Lifesciences Pvt. Ltd. is one of the leading manufacturer and exporter of Geldanamycin. Geldanamycin is a benzoquinone ansamycin antibiotic originally isolated from Streptomyces hygroscopicus. It functions as a potent inhibitor of heat shock protein 90 (Hsp90), a molecular chaperone involved in the stabilization of many oncogenic proteins. By binding to Hsp90, geldanamycin promotes the degradation of these client proteins, disrupting cancer cell growth and survival. It exhibits strong antitumor activity in preclinical studies and has been investigated for potential use in cancer therapy. However, its clinical application is limited by hepatotoxicity and poor solubility. Derivatives like 17-AAG and 17-DMAG have been developed to improve safety and pharmacokinetics. Common research uses include studying protein folding and signal transduction pathways. Buy high quality Geldanamycin from Omsynth Lifesciences.