IMPURITIES AVAILABLE FOR 'Lumacaftor'

Omsynth Lifesciences Pvt. Ltd. is one of the leading manufacturer and exporter of Lumacaftor. Lumacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector used in combination with ivacaftor for the treatment of cystic fibrosis (CF) in patients with the homozygous F508del CFTR mutation. It works by improving the folding, processing, and trafficking of the defective CFTR protein to the cell surface, thereby enhancing chloride ion transport. Lumacaftor helps restore partial CFTR function, reducing mucus buildup and improving lung function and respiratory symptoms. When combined with ivacaftor, it offers a synergistic effect, addressing both the protein folding defect and channel gating dysfunction. Administered orally, it undergoes hepatic metabolism mainly via CYP3A enzymes. Common side effects include chest tightness, dyspnea, nausea, and elevated liver enzymes. Lumacaftor represents a major advancement in mutation-targeted cystic fibrosis therapy. Buy high quality Lumacaftor from Omsynth Lifesciences.