IMPURITIES AVAILABLE FOR 'Neratinib'

Omsynth Lifesciences Pvt. Ltd. is one of the leading manufacturer and exporter of Neratinib. Neratinib is an oral tyrosine kinase inhibitor (TKI) used in the treatment of HER2-positive breast cancer, particularly as extended adjuvant therapy following trastuzumab-based treatment. It works by irreversibly binding to and inhibiting the HER2 and EGFR (ErbB1) receptors, thereby blocking downstream signaling pathways that promote cell proliferation and survival. Neratinib is effective against certain trastuzumab-resistant tumors due to its irreversible mechanism of action. It is administered orally once daily with food. The most common adverse effect is diarrhea, which can be severe and requires proactive management with antidiarrheal agents. Other side effects include nausea, vomiting, rash, and hepatotoxicity. The drug is metabolized by CYP3A4 and should be used cautiously with strong enzyme inducers or inhibitors. Neratinib has shown to reduce recurrence risk in early-stage HER2-positive breast cancer patients. Buy high quality Neratinib from Omsynth Lifesciences.