IMPURITIES AVAILABLE FOR 'Neratinib Maleate'

Omsynth Lifesciences Pvt. Ltd. is one of the leading manufacturer and exporter of Neratinib Maleate. Neratinib maleate is the maleate salt form of neratinib, a potent, irreversible tyrosine kinase inhibitor (TKI) targeting HER2 (ErbB2) and EGFR (ErbB1) receptors. It is used as an oral antineoplastic agent for the extended adjuvant treatment of early-stage HER2-positive breast cancer following trastuzumab-based therapy. By covalently binding to HER2 and EGFR, it blocks downstream signaling pathways involved in cell growth and survival, thereby inhibiting tumor progression. Neratinib maleate is administered orally once daily with food. The most common and significant adverse effect is severe diarrhea, often requiring prophylactic antidiarrheal therapy. Other side effects include nausea, vomiting, abdominal pain, fatigue, and hepatotoxicity. The drug is extensively metabolized via CYP3A4, and dose adjustments may be needed when co-administered with strong CYP3A4 modulators. Buy high quality Neratinib Maleate from Omsynth Lifesciences.