IMPURITIES AVAILABLE FOR 'Nilotinib Monohydrochloride Monohydrate'

Omsynth Lifesciences Pvt. Ltd. is one of the leading manufacturer and exporter of Nilotinib Monohydrochloride Monohydrate. Nilotinib monohydrochloride monohydrate is the hydrated hydrochloride salt form of nilotinib, a selective tyrosine kinase inhibitor (TKI) used for treating Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML). It functions by inhibiting the BCR-ABL tyrosine kinase, which drives abnormal cell proliferation in CML. By stabilizing the enzyme in its inactive conformation, it effectively blocks oncogenic signaling pathways that promote leukemic cell growth. The drug is administered orally, typically twice daily under fasting conditions. It is extensively metabolized by CYP3A4 in the liver, and dose adjustments may be necessary with enzyme inhibitors or in hepatic impairment. Common side effects include rash, nausea, headache, fatigue, and elevated liver enzymes. Serious risks include QT interval prolongation, vascular occlusion, and pancreatitis, requiring regular cardiac and hepatic monitoring during therapy. Buy high quality Nilotinib Monohydrochloride Monohydrate from Omsynth Lifesciences.