IMPURITIES AVAILABLE FOR 'Osimertinib Mesylate'

Omsynth Lifesciences Pvt. Ltd. is one of the leading manufacturer and exporter of Osimertinib Mesylate. Osimertinib mesylate is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) used for the treatment of non-small cell lung cancer (NSCLC) with EGFR T790M mutation or other activating EGFR mutations. It works by irreversibly binding to mutant EGFR, inhibiting downstream signaling pathways that promote tumor cell proliferation and survival. Osimertinib mesylate is effective against both sensitizing and resistant EGFR mutations, including those causing resistance to earlier TKIs like erlotinib and gefitinib. It is administered orally once daily and exhibits excellent blood–brain barrier penetration, offering efficacy in CNS metastases. The drug is metabolized primarily in the liver (CYP3A4/5) and excreted via feces. Common side effects include diarrhea, rash, dry skin, nail toxicity, and QT prolongation. Osimertinib mesylate significantly improves progression-free and overall survival in EGFR-mutant NSCLC patients. Buy high quality Osimertinib Mesylate from Omsynth Lifesciences.