IMPURITIES AVAILABLE FOR 'Ponatinib'

Omsynth Lifesciences Pvt. Ltd. is one of the leading manufacturer and exporter of Ponatinib. Ponatinib is a third-generation tyrosine kinase inhibitor (TKI) designed to treat chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), particularly in patients harboring the T315I mutation resistant to other TKIs. It works by inhibiting BCR-ABL kinase activity, along with several other kinases such as VEGFR, FGFR, and PDGFR, thereby blocking cancer cell proliferation and survival. Ponatinib is administered orally and exhibits high potency and broad kinase inhibition. It is metabolized in the liver (mainly via CYP3A4) and excreted through feces. Common side effects include hypertension, rash, abdominal pain, and thrombocytopenia, while serious risks include arterial occlusion and hepatotoxicity. Ponatinib is reserved for resistant or intolerant CML/Ph+ ALL cases due to its strong efficacy and significant vascular risk profile. Buy high quality Ponatinib from Omsynth Lifesciences.