IMPURITIES AVAILABLE FOR 'Sacubitril Sodium'

Omsynth Lifesciences Pvt. Ltd. is one of the leading manufacturer and exporter of Sacubitril Sodium. Sacubitril Sodium is the neprilysin-inhibiting component of the angiotensin receptor–neprilysin inhibitor (ARNI) combination used with valsartan for heart failure management. It inhibits neprilysin, an enzyme responsible for degrading natriuretic peptides, bradykinin, and other vasoactive substances. By increasing levels of these peptides, sacubitril promotes vasodilation, natriuresis, diuresis, and reduced cardiac remodeling. The drug significantly improves outcomes in heart failure with reduced ejection fraction (HFrEF), including mortality and hospitalization reduction. Sacubitril is administered as a prodrug (sacubitril), converted to the active metabolite LBQ657. It is well absorbed orally and undergoes renal and hepatic elimination. Common adverse effects include hypotension, hyperkalemia, and potential angioedema risk. The compound must not be combined with ACE inhibitors due to elevated angioedema risk. It represents a major therapeutic advancement in chronic heart failure treatment. Buy high quality Sacubitril Sodium from Omsynth Lifesciences